The conduct of clinical research often conflicts with community life even if it is done for the benefit of the public. This can be explained by differences in perception, understanding and respective knowledge of each other’s interests and needs. This slide was designed to support discussions around the issues raised by the need to conduct clinical research in communities which often struggle to undertsand the research and how they can impact on what is being done. It can also be used by communities who want to engage with researchers to facilitate the conduct of mutually beneficial clinical research.