Roger Tatoud

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True science teaches, above all, to doubt and to be ignorant. (Miguel de Unamuno)

Barriers to condom use

Barriers to condom useTo use or not to use a condom for sexual intercourse is the result of a combination of several interacting factors. From the rational decision to choose not to use condoms to that of not being able to choose to use them, there is a broad range of possible accounts.

Addressing poor condom use therefore is not a question of simply promoting them but a question of knowing and understanding these numerous factors, their interactions and additive effects and ultimately understanding what leads people to do what they do or can do in their individual situation with their own perspectives, understanding, resources and options.

A Sustainable Globalisation?

washington vs Geneva ConsensusGlobalisation has been the buzzword of the roaring nineties and with the fall of the Berlin’s wall, the end of the cold war and the victory of capitalism over socialism it has opened a new era in human history. Rightly or not, globalisation has become synonymous with market economy, capitalism and development. Much discussions, books and movies have placed it at the centre of the debate about the future of development with a “New Deal” or a “New Barbarism” as two possible scenarios. As the Washington Consensus is being challenged by the Geneva Consensus, the possibility of a sustainable globalisation, conducive to social justice, human security and environmental protection, being an unrealisable goal is a question of great contemporary interest. To address this question we will examine how globalisation affects social justice, human security and the environment. We will then introduce different views and responses to the globalisation process, which when integrated altogether will provide a framework to answer the question of realizing a sustainable globalisation. Read the rest of this entry »

Biological Factors Affecting HIV Infection

Conditions Affecting HIV Transmission v2Several factors are important in determining if the HIV virus can be passed from an infected person to another one. These include biological and social factors which both relate to the exposed and the “infector” individuals.

This conceptual framework summarises only the biological factors that influence HIV transmission. When assessing the risk of infection, each should be considered in turn and as a whole.

Read the rest of this entry »

Diseases of Poverty

Diseases of PovertyA conceptual framework for understanding the diseases of poverty. Despite tremendous technological and scientific progresses in the understanding of diseases and their management, millions of people in the developing world still die of preventable infections and food scarcity whilst millions of other in the developped world die of diseases of opulence and excess.

HIV Prevention, an Overview

HIV PreventionHIV prevention goes far beyond the simplistic ABC message that hijacks most of the media attention. This figure tries to illustrate the breadth and diversity of the field of HIV prevention (Click to enlarge). It would still need to be further expanded to really cover all the aspects of an ever growing field.

The SYFA Website

SYFA (Save Your Future Association) was founded in 2001 by Farmer Tantoh Nforba and is located in Nkambe, North West Province of Cameroon.

SYFA works with local farmers, youths and children on environmental protection, organic agriculture and home gardening and currently coordinates the activities of 10 environmental groups at local schools, churches and the prison

The project was to create a new website for SYFA that would provide a better window into the work of Farmer Tantoh

Farmer Tantoh training the students

Farmer Tantoh training students from the agricultural school in Nkambe the importance of botanical gardens in rural communities

Since its inauguration, SYFA has helped to prove numerous compounds (houses) in the Binju neighbourhood of Nkambe, as well as designing many gardens at churches, schools and administrative buildings.

“Farmer” Tantoh is from Nkambe, Cameroon. He studied at the Regional College of Agriculture, in Bambili, Cameroon, where his field of study was Agriculture and Rural Development. He specialized in spring water catchments’ protection using sustainable agro-forestry practices.

Tantoh has worked with local youths and low-income farmers, introducing lawn creation and flower gardening and also organic farming techniques adaptable to the tropics thereby protecting the local environment.

Achievement: The SYFA website is up and running since mid-June 2007.

Small Media Volunteer @ GMFA

GMFA was founded in 1992, by a group of gay men who felt that there was not enough HIV prevention work being specifically targeted at gay men. GMFA‘s mission is to improve gay men’s health by increasing the control they have over their own lives.

As a volunteer since 2008, I contribute to the design of information booklets and to the content of GMFA magazine “Fit and Sexy”.

Scientific Publications

  • Fearnside JF, Dumas ME, Rothwell AR, Wilder SP, Cloarec O, Toye A, Blancher C, Holmes E, Tatoud R, Barton RH, Scott J, Nicholson JK, Gauguier D. Phylometabonomic patterns of adaptation to high fat diet feeding in inbred mice. PLoS ONE 3, e1668 (2008).
  • Toye AA, Dumas ME, Blancher C, Rothwell AR, Fearnside JF, Wilder SP, Bihoreau MT, Cloarec O, Azzouzi I, Young S, Barton RH, Holmes E, McCarthy MI, Tatoud R, Nicholson JK, Scott J, Gauguier D.  Subtle metabolic and liver gene transcriptional changes underlie diet-induced fatty liver susceptibility in insulin-resistant mice. Diabetologia 50, 1867-79 (2007).
  • Daly-Burns B, Alam TN, Mackay A. Clark J, Shepherd CJ, Rizzo S, Tatoud R. O’Hare MJ, Masters JR, Hudson DL. A conditionally immortalized cell line model for the study of human prostatic epithelial cell differentiation. Differentiation 75:35–48, (2007).
  • Dumas ME, Barton RH, Toye A, Cloarec O, Blancher C, Rothwell A, Fearnside A, Tatoud R, Blanc V, Lindon JC, Mitchell SC, Holmes E, McCarthy MI, Scott J, Gauguier J, Nicholson JK. Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice. P.N.A.S. 103:12511–12516, (2006).
  • Arya M, Patel HR, McGurk C, Tatoud R, Klocker H, Masters J, Williamson M. The importance of the CXCL12-CXCR4 chemokine ligand-receptor interaction in prostate cancer metastasis. J Exp Ther Oncol. 4, 291-303 (2004).
  • Stephen RL, Gustafsson MC, Jarvis M, Tatoud R, Marshall BR, Knight D, Ehrenborg E, Harris AL, Wolf CR, Palmer CN. Activation of peroxisome proliferator-activated receptor delta stimulates the proliferation of human breast and prostate cancer cell lines. Cancer Res. 64, 3162-70 (2004)
  • Adamson DJA, Frew D, Tatoud R, Wolf CR & Palmer CNA. Diclofenac antagonizes peroxisome proliferator-activated receptor-? signalling. Mol Pharmacol. 61, 7-12 (2002).
  • Maillard M, Cadot B, Ball RY, Sethia K, Perbal B, Edwards D & Tatoud R. Differential expression of novH proto-oncogene in human prostate cell lines and tissues. Mol Pathol. 54, 275-280 (2001).
  • Tatoud R. Insulin-like growth factor (IGF) network in prostate pathologies. Pr Cancer Pr Dis 2,66-69 (1999).
  • Sangrajrang S, Denoulet P, Millot G, Tatoud R, Podgorniak MP, Tew KD, Calvo F, & Fellous A. Estramustine resistance correlates with tau over-expression in human prostatic carcinoma cells. Int J Cancer 77,626-631 (1998).
  • Sangrajrang S, Denoulet P, Laing NM, Tatoud R, Millot G, Calvo F, Tew KD & Fellous A. Association of estramustine resistance in human prostatic carcinoma cells with modified patterns of tubulin expression. Biochem Pharmacol 55, 325-331 (1998).
  • Le Moyec L, Millot G, Tatoud R, Calvo F & Eugene M. Lipid signals detected by NMR proton spectroscopy of whole cells are not correlated to lipid droplets evidenced by the Nile red staining. Cell Molec Biol 43, 703-709, (1997).
  • deCremoux P, Ravery V, Podgorniak MP, Chevillard S, Toublanc M, Thiounn N, Tatoud R, Delmas V, Calvo F & Boccon-Gibod L. Value of the preoperative detection of prostate-specific-antigen-positive circulating cells by nested RT-PCR in patients submitted to radical prostatectomy. Eur Urol 32, 69-74 (1997).
  • Prévost G, Benamouzig R, Veber N, Fajac A, Tatoud R, Degeorges A. & Eden P. The somatostatin receptor subtype 2 is expressed in normal and tumoral human tissues. Cancer Detection & Prevention 21, 62-70 (1997)
  • Lebbe C, Pellet C, Tatoud R, Agbalika F, Dosquet P, Desgrez JP, Morel P & Calvo F. Absence of human herpesvirus 8 sequences in prostate specimens. AIDS 11, 270 (1997).
  • Lebbé C, Tatoud R, Morel P, Calvo F, Euvrard S, Kanitakis J, Faure M, & Claudy A. Human herpesvirus 8 sequences are not detected in epithelial tumors from patients receiving transplant. Arch Dermatol 133, 111 (1997).
  • Degeorges A, Tatoud R, Fauvel-Lafève F, Podgorniak MP, Millot G, de Cremoux P. & Calvo F. Stromal cells from human benign prostate hyperplasia produce a growth inhibitory factor for LNCaP prostate cancer cells. Int. J. Cancer 68, 207-214 (1996).
  • Le Moyec L, Tatoud R, Degeorges A, Calabresse C, Bauza G, Eugène M. & Calvo F. Multidrug resistance and cellular lipids detected by proton nuclear magnetic resonance spectroscopy in K562 leukemia cell line. Cancer Res 56, 3461-3467 (1996).
  • Tatoud R, Degeorges A, Prévost G, Hoepffner JL, Gauvillé C, Millot G, Thomas F. & Calvo F. Somatostatin receptors in prostate tissues and derived cell cultures, and the in vitro growth inhibitory effect of BIM-23014 analog. Mol Cell Endocrinol 113, 195-204, (1995).
  • Tatoud R, Desgranchamps F, Degeorges A, & Thomas, F. Les facteurs de croissances peptidiques de la prostate. Pathol Biol 41, 731-740, (1993).
  • Le Moyec L, Tatoud R, Eugène M, Gauvillé C, Primot I, Charlemagne D, & Calvo F. Cell and lipid membrane lipid analysis by proton magnetic resonance spectroscopy in five breast cancer cell lines. Br J Cancer 66, 623-628, (1992).
  • Desgranchamps F, Tatoud R, Cussenot O, Teillac P, & Leduc A. Facteurs de croissance prostatiques et hypertrophie bénigne de la prostate. Etat des connaissances actuelles et perspectives. Progres Urol 2, 1031-1044 (1992).
  • Le Moyec L, Eugène M, Gauvillé C, Tatoud R, Ouvrard BN, & Calvo F. Profils lipidiques de lignées de cancer du sein: spectrométrie par résonance magnétique nucléaire du proton. C R Acad Sci Paris, 312(III), 25-30, (1991).

Fundraiser for The Food Chain

Since 2003 volunteer and chair (2003-2006) of the Community Fundraising Committee of The Food Chain whose mission is to improve the health and well being of London’s population living with HIV by alleviating hunger and malnutrition.

The Food Chain is a UK registered charity delivering meals every week to more than 500 users across London, free of charge, since 1988. Every Sunday, Food Chain volunteers prepare and deliver delicious, nutritionally balanced, individually tailored meals and groceries to people who, because of their illness, are housebound and unable to provide or prepare meals for themselves. Read the rest of this entry »

Challenges facing the UK Research Base

The academic year 2007 started with a “Time Bomb” uncovered by the Higher Education Policy Institute (HEPI): student in England are having it the easy way with an average of 26 hours a week spent studying compared to 30 in Ireland, 35 in France and 41 in Portugal. Variations are wide depending on the subject but with less than 15 hours of tuition a week, fears and concerns are raised that Higher Education is going down the drain and will have serious academic consequences for the future of Science in the UK. Read the rest of this entry »